CD9

CD9 (tetraspanin-29 / TSPAN-29)

一行要約

Tetraspanin スーパーファミリーに属する 4 回膜貫通型タンパクで、small EV (エクソソーム) 表面マーカーとして MISEV2018/2023 ガイドラインで CD63 / CD81 と並ぶ “tetraspanin trio” の一つに位置づけられる。Tetraspanin-enriched microdomain (TEM) を構成して membrane organization、cargo selection、EV biogenesis、target cell uptake に関与する。CD9 は癌においてダブルエッジで、転移抑制 (移動抑制) と EV 含有 cargo を介した転移促進の両面を持つ文脈依存的因子。

主要エビデンス

EV マーカーとしての位置づけ: MISEV ガイドラインで EV (small EV / exosome) の必須キャラクタリゼーション 3 マーカー (CD9 / CD63 / CD81) の一つ。flow cytometry / Western blot / nanoFCM 等で広範に使用される。

腫瘍生物学: CD9 高発現は乳癌・肺癌の一部で予後良好と関連、一方で腫瘍由来 EV 上の CD9 が血小板凝集 / 血管透過性亢進を介して転移を促進する報告も。

メカニズム

Tetraspanin-enriched microdomain (TEM): CD9 は他の tetraspanin (CD63, CD81)、integrin、growth factor receptor と物理的にクラスタリングして TEM を形成。TEM は EV biogenesis 段階で cargo sorting platform として機能し、放出後は target cell の認識・uptake を仲介する。

EV 上での役割: CD9-CD81 ヘテロ二量体が exosome 表面に高密度で発現し、recipient cell の対応 receptor (integrin など) と相互作用して指向性 uptake を駆動する。

関連エンティティ・概念

• Tetraspanin family: CD63 / CD81 — EV マーカー三兄弟
• Pathway: Exosome-biogenesis-pathway
• EV biogenesis: TSG101 / ALIX / Syntenin / Rab27
• Concept: EV-mediated-intercellular-communication / EV-organotropism
• MOC: cancer-extracellular-vesicles

関連論文

直近 30 件のみ表示中 (関連 205 件)。 全件は MOC ページ または Obsidian (source Markdown) から辿れます。

Basic-Extracellular vesicles

• Jung et al. ACSSens 2026 — Wash-free digital detection of tumor extracellular vesicles via plasmonic droplet microfluidics
• Schmidt et al. AmJPhysiolCellPhysiol 2026 — Extracellular vesicles in exhaled breath condensate as emerging biomarkers in lung cancer
• Xue et al. CancerCellInt 2026 — Tissue-derived extracellular vesicles comparing ts-EVs and te-EVs in extraction, characteristics and research trends
• Hudson et al. CancerLett 2026 — Human neural stem cell-derived extracellular vesicles improve cognitive function following glioma chemoradiation therapy
• Lucotti et al. Cell 2025 — Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via
• Peng et al. CellMolBiolLett 2026 — Lactate-activated astrocytes promote NSCLC brain metastasis through extracellular vesicle-mediated miR-8085trim67elk1
• Tang et al. CellSignal 2025 — N2 neutrophils induce cell stemness reprogramming to promote gastric cancer progression via exosomal miRNAs
• Yang et al. JClinInvest 2025 — HIF-1 promotes murine breast cancer brain metastasis by increasing production of integrin beta3-containing
• Pontis et al. JExpClinCancerRes 2026 — Circulating extracellular vesicles from early-stage lung cancer patients trigger endothelial activation to drive
• Crescitelli et al. JExtracellVesicles 2025 — Recommendations for studying in situ extracellular vesicles from solid tissue
• De et al. JExtracellVesicles 2026 — Characterizing the fate of anti-CS1 nanobody displaying extracellular vesicles in multiple myeloma
• Li et al. JExtracellVesicles 2026 — Exosomal oleic acid promotes lymphangiogenesis and nodal metastasis in cervical cancer via the AKTmTOR pathway
• Seo et al. JExtracellVesicles 2026 — Proteomic profiling of human extracellular vesicles reveals diagnostic biomarkers for colon adenocarcinoma
• Walther et al. JExtracellVesicles 2026 — Therapeutic poxviruses induce the secretion of immunostimulating and anti-tumoral extracellular vesicles
• Liu et al. JNanobiotechnology 2026 — Overcoming blood-brain barrier and chemoresistance in glioblastoma by angiopep-2-modified NK cell-derived extracellular
• Cai et al. MolCancer 2026 — Extracellular vesicles in solid tumors from tumor ecology to engineered therapeutics
• Tian et al. NatBiomedEng 2026 — Skeletal-muscle-targeted non-viral delivery of full-length DMD mRNA for duchenne muscular dystrophy
• Son et al. NatCommun 2025 — Fusogenic lipid nanoparticles for rapid delivery of large therapeutic molecules to exosomes
• Shen et al. NatCommun 2026 — Co-enrichment of proteins in extracellular vesicles
• Chaudhari et al. NatRevBioeng 2026 — The status of extracellular vesicles a drug carriers and therapeutics
• Wei et al. NucleicAcidsRes 2026 — SVAtlas a comprehensive single extracellular vesicle omics resource

Basic-Immunotherapy

• Kim et al. NatImmunol 2026 — Engineering NK and T cells with metabolite-sensing receptors to target solid tumors

Basic-Liquid-biopsy

• Leporati et al. Cytopathology 2026 — From tumour to bloodstream advancing PD-L1 testing with liquid biopsies in non-small cell lung cancer

Basic-Neutrophil and myeloid cell

• Hsu et al. Cell 2025 — Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution
• Li et al. MolImmunol 2025 — Neutrophil-derived exosomal S100A8 aggravates lung injury in sepsis by inducing pyroptosis
• Kusch et al. Science 2026 — Platelet-derived integrin-and tetraspanin-enriched tethers exacerbate severe inflammation

Basic-Others

• Tzouanas et al. Cell 2026 — Hepatic adaptation to chronic metabolic stress primes tumorigenesis

Clinical-Novel modalities

• Horowitz et al. SciTranslMed 2026 — Cd39+cd49a+cd103+ cytotoxic tissue-resident natural killer cells infiltrate and control solid epithelial tumor growth

Clinical-Others

• Luo et al. NatRevCancer 2026 — N6-Methyladenosine an RNA modification as a central regulator of cancer
• Liu et al. NatRevMolCellBiol 2026 — Regulation and function of specialized membrane protrusions in intercellular communication